5-MTHF Plus B12

5-MTHF Plus B12 60 tablets is the most biologically active form of the water-soluble B vitamin, folate. It is the preferred form of folate supplementation due to an array of conditions that can limit conversion or absorption of folic acid. Data indicate that supplementing with 5-MTHF increases plasma folate more effectively than folic acid. Methylcobalamin, which is found in the 5-MTHF plus B12 formula, is a highly pure form of methylcobalamin that does not use any harmful solvents during manufacture.*

Benefits of 5-MTHF

• Support Methylation*
• Support Nervous System Health*
• Support Normal Cellular Proliferation (Including Red Blood Cells)*
• 5-MTHF Does Not Contribute to Unmetabolized Folic Acid Accumulation (UMFA)*
• 5-MTHF Supports Healthy Serum Folate Levels*
• 5-MTHF Supports a Healthy Pregnancy Outcome*

5-MTHF Plus B12 formula combines Quatrefolic and vitamin B12 as MecobalActive™ in cherry-flavored, quick-dissolve tablets. MecobalActive is a pure form of methylcobalamin. Many vitamin B12 supplements on the market contain cyanocobalamin. The liver is able to convert a small amount of cyanocobalamin to methylcobalamin; however, methylcobalamin is the preferred form because it is the bioactive form and is therefore better utilized. Another point of interest regarding B12 supplementation is the commonly held belief that intramuscular injections of B12 are more effective than oral supplementation. In fact, oral supplementation is just as effective and carries the added benefits of lower cost and ease of administration. Unlike other sources of methylcobalamin on the market, MecobalActive does not use any harmful solvents during its manufacture. The patented, advanced production methods used to create MecobalActive also result in a methylcobalamin with greater purity and lower moisture, which translates to greater stability.*

Quatrefolic® In XYMOGEN’s formulas, 5-MTHF is provided as Quatrefolic—the glucosamine salt of 5-MTHF. Quatrefolic is proven to have greater stability, solubility, and bioavailability over the commonly used calcium salt form of 5-MTHF. In a randomized crossover study, subjects received 400 mcg/d of Quatrefolic or 5-MTHF calcium salt. Titernormalized Cmax and AUC demonstrated a 10% higher bioavailability of Quatrefolic.[8] Quatrefolic has several in vitro and in vivo preclinical and clinical studies to characterize and assure the safety profile of the product.*

Vitamin B12 supports healthy methylation through its roles in the synthesis of methionine from homocysteine and synthesis of S-adenosylmethionine (SAMe). As an example of its importance in homocysteine metabolism, one study showed that the addition of B12 to a folate regimen had a greater impact (7%) on homocysteine than did folate alone. Like folate, erythroblasts require vitamin B12 for proliferation during their differentiation.[14] B12 is important for neurological health, and chronic insufficiency can affect the spinal cord, peripheral nerves, the optic nerve, and the brain. Research also supports a role for methylcobalamin supplementation in modulating melatonin secretion, enhancing light sensitivity, normalizing circadian rhythms, and improving sleep-wake cycles.*

Disclaimer: These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.