Premier Research Labs



Acemannan - The Most Biologically Active Component of Aloe vera

Aloe is one of the oldest plants mentioned in ancient records due to its robust properties and health benefits. It is known that ancient Chinese and Egyptians used Aloe vera to address a plethora of health concerns. Premier Aloe features premier quality inner leaf Aloe vera that has been meticulously grown and harvested from the pristine countryside in Central America.  At the time of harvest, it is immediately processed using a proprietary freeze-drying method to maximally preserve the short-chain, gastrointestinal supporting polysaccharide called acemannan, naturally inherent in aloe.  When a fresh lot of aloe arrives at our facility for processing, our scientists begin testing by employing Proton Nuclear Magnetic Resonance Spectroscopy (H NMR) to execute an entire panel of laboratory tests on this raw material to make sure that it satisfies our internal testing criteria.

The polysaccharide, acemannan, is predominately found in the inner leaf gel of Aloe vera and has been identified as one of the most biologically active and beneficial components in Aloe vera.  Extensive research has now characterized its chemical structure to be rich in the monosaccharides, mannose, glucose and galactose, which count among the eight essential monosaccharides that play a critical role in many aspects of human nutrition and health.

The Essential Role Of Mannose In Human Health

Scientific research has demonstrated that the essential role of mannose in human health is specific to the body’s advanced mechanisms to extract mannose from the diet through its symbiotic relationship with probiotic microorganisms. Once digested, mannose is effectively metabolized at the liver, then secreted into the bloodstream and circulated throughout the body.

Our aloe product accesses the potent benefits of nutritional glycobiology of the Aloe vera plant which is an excellent source of glyconutrients. Acemannan (an acetylated mannan) is the key bioactive agent contained in the inner leaf gel of aloe. Research indicates that acemannan may support Immune modulation.

Science has reported that mannose’s biological activity is able to target cell-to-cell communication to promote healthy biological responses during times of stress. The body’s innate responses are regulated in part by glycoproteins (which have a carbohydrate attached by a covalent bond) or glycolipids (which contain oligosaccharides) chains that are present on the surface of the cells. These molecules promote cell-to-cell site activity that is critical to initiate favorable biological responses.

Premier Aloe: Features A Significant Amount Of Naturally Occurring Acemannan

Acemannan and other polysaccharides have been extensively researched in Aloe Vera and are considered to be some of the most biologically active and beneficial components in the plant. By using advanced H NMR analysis, PRL scientists routinely examine the polysaccharide composition and also authenticate Premier Aloe for its naturally occurring highly beneficial acemannan content as well as other key components.


    Disclaimer: These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

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