Klaire Labs



A variety of genetic and acquired factors can disrupt the small intestine brush border, which may result in low activity of brush border enzymes. SIBB-Zymes™ supplies a blend of enzymes normally found in the small intestinal brush border that are critical for the final steps of carbohydrate and protein digestion. Disaccharide enzymes (lactase, maltase, and sucrase) are supplied together with glucoamylase to assist optimal cleaving of sugars and carbohydrates that if left undigested may affect absorption and microbial fermentation, contributing to a shift in the balance of yeast and bacteria.

SIBB-Zymes™ includes an active enzyme blend of peptidase and protease with dipeptidyl peptidase IV (DPP-IV) activity. Peptidase and protease enzymes help break down plant and animal proteins, including casein (milk/dairy products), gluten (wheat, rye, oats, barley, and other grains), and soy. Peptidase enzymes that express DPP-IV activity are especially effective in breaking down proline-rich exorphin (opiate-acting) peptides derived from incompletely digested casein, gluten, and soy that may influence central nervous system function in some individuals. SIBB-Zymes™ can help break down dietary disaccharides and oligosaccharides, including lactose.

Enzymes Included in SIBB-Zymes:

  • Glucoamylase is an enzyme that facilitates the digestion of sugars and long chain carbohydrates found in foods like corn, wheat, rice, and potatoes that, if left undigested, may lead to incomplete absorption with microbial fermentation, altering the balance of yeast and bacteria in the gut.

  • Lactase is an essential enzyme for the complete digestion of lactose, a carbohydrate in milk. Approximately 65% of the human population has a reduced ability to digest lactose after infancy. Lactase has been included to support the digestion of lactose and dairy products.

  • Maltase is a carbohydrate-digesting enzyme that is part of the final step of the digestion of carbohydrates and a naturally occurring sugar (maltose) that is found in malt, grains, and many processed foods.

  • Sucrase (invertase) digests what is commonly known as table sugar, as well as the components of complex carbohydrates. In humans, sucrase is linked with isomaltase. Unfortunately, most plant-derived sucrase supplements do not contain isomaltase which makes the inclusion isomaltase activity an important component of this formula.

  • The protease/peptidase complex contains peptidases and proteases that help break down difficult-to-digest proteins both from the ends of protein chains and from within. The complex also provides enzymes with dipeptidyl peptidase IV, or DPP-IV, activity, essential for the complete breakdown of proline-rich proteins and the inactivation of exorphins.

Free of the following common allergens: milk/casein, eggs, fish, shellfish, tree nuts, and peanuts. Contains no artificial colors, flavors, or preservatives. 

Disclaimer: These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

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